Fill in the blanks with ONE suitable word.
SCIENTISTS COULD STOP THE AGING PROCESS AFTER NEW GENETIC BREAKTHROUGH REVEALS HOW OUR BODIES BREAK DOWN OVER TIME
The way DNA is packaged inside cells could hold the 1) __________ to slowing human ageing and may even play a 2) __________ in diseases such as cancer, diabetes and Alzheimer’s Disease.
Scientists studying a rare disorder 3) __________ as Werner syndrome have discovered a genetic fault that causes people with the condition to age prematurely.
And they found this fault leads to tightly packed bundles of DNA in human cells – heterochromatin – to become disorganised.
The researchers at the Salk Institute for Biological Studies in La Jolla, California, and the Chinese Academy of Science now hope to investigate to see 4) __________ there may be ways of slowing or reversing the process and see if this can have an impact on human health in old age.
They claim it is also possible that disruption of the heterochromatin may be related with diseases such as some cancers, diabetes and Alzheimer’s Disease, 5) __________ they have not expanded on these claims.
The study, published in the journal Science, used cells 6) __________ from patients suffering from Werner syndrome.
Professor Juan Carlos Izpisua Belmonte, a geneticist at the Salk Institute who was one of the lead authors of the study, said: ‘Our findings show that the gene mutation that causes Werner syndrome results 7) __________ the disorganisation of heterochromatin, and that this disruption of normal DNA packaging is a significant driver of aging.
‘More broadly, it suggests that accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular ageing.
‘This 8) __________ the question of whether we can reverse these alterations – like remodelling an old house or car – to prevent, or even reverse, age-related declines and diseases.’
Werner syndrome is a rare disorder that occurs in one in 9) __________ 100,000 births and tends to appear once people reach puberty.
Sufferers show growth retardation, wrinkling, premature greying of hair, cardiovascular problems, type 2 diabetes, osteoporosis and some types of cancers.
Professor Belmonte, 10) __________ with colleagues from the Chinese Academy of Sciences in Beijing, used cloning techniques to produce embryonic stem cells with DNA from people with Werner syndrome.
Adapted from © The Daily Mail
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